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折疊霍夫曼重排反應中的溴化

N-溴代琥珀酰亞胺在強堿（例如1,8-二氮雜雙環[5.4.0]十一碳-7-烯（DBU））的狀態下可以將一級酰胺經由霍夫曼重排反應產生中間產物異氰酸酯。異氰酸酯則與帶有羥基的化合物（例如甲醇）反應生成易水解和分離的氨基甲酸。

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